Revista Eletrônica de Potência (Brazilian Journal of Power Electronics)

Palavras Chaves: Eletropermeabilização, Gerador de Marx, Multiplicador de Tensão

Resumo
Este artigo apresenta um circuito Gerador de Marx (GM) bipolar, capaz de gerar pulsos com parâmetros elétricos destinados à eletropermeabilização biológica. Este procedimento consiste em aplicar campos elétricos intensos em tecidos vivos para a criação de poros em suas membranas celulares, e com isso otimizar procedimentos como introdução de medicamentos, transferência genética, fusão molecular e até acelerar a morte de um conjunto celular. É desenvolvido um GM bipolar capaz de obter tensão pulsada de 1200 V a partir de uma entrada em 300 V. O multiplicador de tensão se baseia em um sistema com capacitores conectados ora em paralelo e ora em série. Testes práticos foram realizados com uma amostra vegetal, a fim de analisar o funcionamento do gerador, explorando os múltiplos parâmetros ajustáveis proporcionados pelos circuitos.

Title: BIPOLAR MARX GENERATOR BASED ON FULL-BRIDGE TOPOLOGY APPLIED TO BIOLOGICAL ELECTROPERMEABILIZATION

Keywords: Electroporation, Marx Generator, Voltage Multiplier

Abstract
This paper presents a bipolar Marx Generator (MG), circuit that generates electrical pulses with parameters applied to biological electroporation. This procedure consists of applying intense electric fields in living tissues to create pores in their cell membranes, and thereby optimize procedures such as the introduction of drugs, genetics transfer, molecular fusion and even accelerate the death of a group of cells. Aiming this application, a bipolar MG capable of obtaining 1200 V pulses from a 300 V source was developed. The voltage multiplier works through the parallel or series connection of its capacitors. Practical tests in laboratory were made with a vegetable sample, in order to analyze the generator’s operation, exploring the multiple adjustable parameters provided by the circuit.

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